The Human
Microbiota & Brain
Diseases | 3rd edition

Therapeutic Targets

2 April 2019

Geneva University Hospitals

Context

The past two years have seen an exponential increase of lay and scientific publications on the effects of the trillions small guests that each of us more or less willingly hosts even in the most secluded and intimate folds and holes of our body. High time, given that the power house of eukaryotic cells, mitochondria, are but ancient bacteria.

Reports have been published on the association of some bacterial strains in the guts (gut bacteria being by far the most represented microbial community) on human physiology (infant growth….) and somatic diseases (obesity, alcoholism, irritable-bowel syndrome and rheumatoid arthritis) and brain diseases (depression, autism, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease).

Reports have multiplied of animal experiments showing that some natural features (resistance to infections and carcinogenic exposures) can be transferred from one animal to another by gut bacteria transfer. Not only, but it is increasingly clear that a number of environmental events can affect the bacterial composition of gut flora (diet, physical exercise, exposure to cold), that the animals with the modified version of the gut flora acquire specific physical and behavioural features (weight changes, sociability, motor impairments), and that such features can be transferred to non-exposed animals by  gut bacteria transfer.

How much of these results is journalism hype and how much is sound science? How close (or how far for that matter) are we from gut flora manipulations in humans to protect from dreaded brain diseases?

The 3rd edition of this conference, which attracted 500 participants from Europe, will try and give an answer thanks to a panel of renowned national and international experts on the microbiota and the brain.

Aims

To update physicians and scientists on the latest discoveries on the role of the GMB in neuropsychiatric and neurodegenerative diseases.

To identify leads for microbiota-based interventions for brain diseases.

Public

  • Physicians
  • Neuroscientists
  • Biologists

PRELIMINARY PROGRAM

  • MAIN LECTURE | PATHOPHYSIOLOGY
13.30

Welcome Address

13.45

Introduction

13.50

The pervasive reach of host-microbial mutualism

14.05

Q&A

  • ORAL COMMUNICATIONS | PHYSIOLOGY OF THE MICROBIOTA | Chair: Mirco Schmolke
14.10

Stability of the human faecal microbiome

14.25

Q&A

14.30

Host microbiota constantly control maturation and function of microglia in the CNS

14.45

Q&A

  • MAIN LECTURE | NON - BRAIN DISEASES
14.50

Introduction

14.55

Local and systemic distortion of microbiota homeostasis by influenza A virus infection give rise to bacterial super infection

15.10

Microbiota-based treatment of non-brain diseases: leads for neurodegenerative diseases

15.25

Q&A

  • ORAL COMMUNICATIONS | ALZHEIMER’S DISEASE | Chair: Jacques Schrenzel
15.35

Brain amyloidosis, pro-inflammatory gut bacteria, and peripheral inflammation in cognitively impaired elderly

15.50

Active Invasion of Porphyromonas gingivitis and Infection-Induced Complement Activation in ApoE/Mice Brains

16.05

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

16.20

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease

16.35

Q&A

16.55

Break

  • MAIN LECTURE | FUTURE RESEARCH AVENUES
17.25

Introduction

17.30

From descriptive taxonomy to functional taxonomy of the microbiota

17.45

Q&A

  • ORAL COMMUNICATIONS | MICROBIOTA MANIPULATION AND BRAIN HEALTH | Chair: Giovanni B Frisoni
17.50

Microbiota modulation counteracts Alzheimer’s disease progression influencing neuronal proteolysis and gut hormones plasma levels

18.05

Gut microbiota as a target to attain longevity

18.20

Q&A

18.30

Conclusion

19.00

Cocktail

Organisers

GIOVANNI B. FRISONI
Faculty of Medicine & University Hospitals of Geneva

...

JACQUES SCHRENZEL
Faculty of Medicine & University Hospitals of Geneva

...

MIRKO TRAJKOVSKI
Faculty of Medicine, University of Geneva

...

SCIENTIFIC BOARD

Tristan Bolmont, Annamaria Cattaneo, Jean François Démonet, Stephan Eliez, Taoufiq Harach, Gabriel Gold, Moira Marizzoni, Philippe Millet, Benjamin Tournier.

POST GRAD CME

CME credits will be requested to: Association des médecins du canton de Genève,  FAMH Medical Laboratories of Switzerland, Swiss Neurological Society, Swiss Professional Society of Geriatrics, Swiss Society of Gastroenterology, Swiss Society of General Internal Medicine, Swiss Society of Psychiatry and Psychotherapy.

Presentations

Presentations will follow the traditional podium and slide mode or an innovative interactive mode.

Draft Presentations for Registered Congress Participants
The presenter will drafts a Powerpoint presentation including audio to illustrate the content of the slide (same audio that the presenter would deliver in person).
Ask a question to the presenter
The Powerpoint presentation is shared with registered congress participants 1 week before the meeting via a registered member only of the congress website. Registered congress participants will send questions to the congress organisers that will be answered in person by the presenter during the congress.
The presenter will answer questions sent
At the congress, the audience will be shown the Powerpoint presentation, at the end of which, from the podium, the presenter will answer questions sent via mail or asked in person.

Location

HUG Hôpitaux Universitaires de Genève

Auditoire Marcel Jenny
Rue Gabrielle-Perret-Gentil 4, 1205 Genève